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【结 构 式】 
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【药物名称】Tranilast, SB-252218, Rizaben 【化学名称】N-(3',4'-Dimethoxycinnamoyl)anthranilic acid 【CA登记号】53902-12-8 【 分 子 式 】C18H17NO5 【 分 子 量 】327.33989 |
【开发单位】Kissei (Originator), GlaxoSmithKline (Licensee) 【药理作用】Antiallergic Ophthalmic Agents, Antiallergy/Antiasthmatic Drugs, Asthma Therapy, CARDIOVASCULAR DRUGS, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, RESPIRATORY DRUGS, Restenosis Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis |
合成路线1
By condensation of anthranilic acid (o-aminobenzoic acid) (I) with 3,4-dimethoxycinnamoyl chloride (II) by means of pyridine in refluxing chloroform.
| 【1】 Harita, K.; et al.; Aromatic carboxylic amide derivatives. DE 2402398; FR 2214476; GB 1446141; JP 49093335; US 3940422 . |
| 【2】 Hillier, K.; Castaner, J.; N-5'. Drugs Fut 1977, 2, 1, 42. |
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