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【结 构 式】 
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【药物名称】TMB-8 【化学名称】8-(N,N-Diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride 【CA登记号】57818-92-5 (free base) 【 分 子 式 】C22H38ClNO5 【 分 子 量 】432.00486 |
【开发单位】Aldrich (Originator) 【药理作用】Calcium Channel Blockers, Muscarinic M3 Antagonists |
合成路线1
TMBN's have been synthesized by the method of Sastry and Lasslo by dissolving 0.05 moles of 3,4,5-trimethoxybenzoic acid (I) in 300 ml of dry benzene, to which 100 ml benzene containing 0.05 moles n-(N,N-dimethylamino) (CH2)nOH (II) was added dropwise with constant stirring. The temperature was maintained at 29-34 C. The reaction mixture was agitated for 2 additional hours at room temperature, then refluxed for 2 hours on steam bath. The product was recrystallized from benzene or from a mixture of ether and benzene. TMB-8 is considered more difficult to synthesize than TMB-6.
