INO-2628(free base), INO-2628CZ, -Drug Synthesis Database

【结构式】

【药物名称】INO-2628(free base), INO-2628CZ

【化学名称】1,4-Bis(cyclopropylmethyl)piperazine dihydrochloride
　　　　　　N,N-Dicyclopropylmethylpiperazine dihydrochloride

【CA登记号】82909-97-5, 82909-96-4 (free base)

【分子式】C₁₂H₂₄Cl₂N₂

【分子量】267.24448

【开发单位】Innothera (Originator)

【药理作用】CARDIOVASCULAR DRUGS, Heart Failure Therapy

合成路线1

The reaction of cyclopropylmethyl chloride or cyclopropylmethyl bromide (Ia-b) with piperazine (II) by means of Na2CO3 in anhydrous DMF gives N,N-dicyclopropylmethylpiperazine.

参考文献中间体

【1】 Robba, M.F.; Aurousseau, M.E. (Laboratoire Innothera SA); Cyclopropylmethyl piperazines, the process for preparing the same and their use in therapeutics. CA 1171085; EP 81401516; FR 8021527; JP 163681; US 4474783 .
【2】 Leclerc, G.; INO-2628 CZ. Drugs Fut 1985, 10, 11, 907.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(Ib)	22277	Cyclopropyl bromide; 1-(Bromomethyl)cyclopropane	7051-34-5	C₄H₇Br	详情	详情
(Ia)	29776	1-(chloromethyl)cyclopropane	5911-08-0	C₄H₇Cl	详情	详情
(II)	10355	Diethylenediamine; Piperazine	110-85-0	C₄H₁₀N₂	详情	详情

Extended Information