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【结 构 式】 
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【药物名称】MOSE 【化学名称】4,4'-(Selenodi-2,1-ethanediyl)bismorpholine dihydrochloride 【CA登记号】83616-20-0, 73511-88-3 ([75Se]-labeled) 【 分 子 式 】C12H26Cl2N2O2Se 【 分 子 量 】380.21922 |
【开发单位】State University of New York, Buffalo (Originator) 【药理作用】DIAGNOSTIC AGENTS, Radiopharmaceuticals, Radiopharmaceuticals for Brain Imaging |
合成路线1
Selenious acid (H2SeO3) is successfully reduced by sodium borohydride (in excess) to form NaHSe (II). After reacting with beta-morpholinoethyl chloride (III) the bis(beta-morpholinoethyl)selenide is the only product and no diselenide is isolated. The unreacted NaHSe is reoxidized during the workup to insoluble Sex, which is easily separated by filtration. The product is separated from unreduced H2SeO3 by chloroform extraction. This procedure is also useful for the preparation radioactive MOSE using Se-75 (t1/2 = 120 days). The purity of the extracted material is 95%.
| 【1】 Gandolfi, C.; Pellegata, R. Fumagalli, A. (Pharmacia & Upjohn SpA); 13,14-Dehydro-11-deoxy-prostaglandins and process for their preparation. US 4293705 . |
| 【2】 Kung, H.F.; Kostyniak, P.J.; Mose. Drugs Fut 1985, 10, 9, 748. |