Riodoxol, -Drug Synthesis Database

【结构式】

【药物名称】Riodoxol

【化学名称】2,4,6-Triiodoresorcine
　　　　　　2,4,6-Triiodo-1,3-benzenediol
　　　　　　2,4,6-Triiodo-1,3-dihydroxybenzene

【CA登记号】19403-92-0

【分子式】C₆H₃I₃O₂

【分子量】487.80281

【开发单位】All-Russian Chem.-Pharm. Res. Inst. (Originator)

【药理作用】Antibacterial Drugs, Antifungal Agents, ANTIINFECTIVE THERAPY, Antiviral Drugs, Dermatologic Drugs

合成路线1

The method of synthesis for 2,4,6-triiodoresorcine comprises a stage of resorcin (I) iodination with iodine chloride in the presence of hydrochloric acid as a catalyzer. The reaction mixture is allowed to stand for 1 h at the temperature of 20-5 C. The precipitate is filtered and dried at 50 C. Triiodoresorcine yield is 93.6% (crystallized from CCl4).

参考文献中间体

【1】 Nikolaeva, E.S.; Riodoxol. Drugs Fut 1985, 10, 1, 35.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10361	1,3-Dihydroxybenzene; m-Dihydroxybenzene; Resorcinol; Resorcin; 1,3-Benzenediol	108-46-3	C₆H₆O₂	详情	详情

Extended Information