Cisplatin, DDP-H, NSC-119875, CPDC, CACP, CDDP, Cis-DDP, Platinex, Briplatin, Randa, Platinol-AQ, Platinol, Neoplatin, -Drug Synthesis Database

【结构式】

【药物名称】Cisplatin, DDP-H, NSC-119875, CPDC, CACP, CDDP, Cis-DDP, Platinex, Briplatin, Randa, Platinol-AQ, Platinol, Neoplatin

【化学名称】cis-Diaminedichloroplatinum(II)
　　　　　　(SP-4-2)-Diaminedichloroplatinum

【CA登记号】15663-27-1

【分子式】H₆Cl₂N₂Pt

【分子量】300.05722

【开发单位】Bristol-Myers Squibb (Originator), Ferring (Licensee), Nippon Kayaku (Codevelopment)

【药理作用】Bladder Cancer Therapy , Liver Cancer Therapy, Oncolytic Drugs, Ovarian Cancer Therapy, Solid Tumors Therapy, BIRC4 Expression Enhancers, DNA Alkylating Drugs, Platinum Complexes, TNFSF6 Expression Inhibitors

合成路线1

The reduction of potassium hexachloroplatinate (I) with hydrazine dihydrochloride (II) in hot water gives potassium tetrachloroplatinate (III), which is finally treated with NH4Cl or NH4OAc and aqueous ammonia.

参考文献中间体

【1】 Lebendinskii, V.V.; Golovnya, V.A.; Ammonia compounds of bivalent platinum. Izvest Sektora Platiny i Drug Blagorod Metal Inst Obshchei i Neorg Khim Akad Nauk S.S.S.R 1947, 20, 95-98.
【2】 Cowan, D.O.; Kauffman, G.B.; cis- and trans-Dichlorodiammineplatinum (II). Inorg Synth 1963, 7, 239-245.
【3】 Castaner, J.; Woodman, R.J.; Cisplatin. Drugs Fut 1978, 3, 8, 574.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	27344	hydrazine	302-01-2	H₄N₂	详情	详情

Extended Information