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【结 构 式】 
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【药物名称】Disodium pamidronate, Pamidronate sodium, CGP-23339A, AHPrBP, CGP-23339AE(pentahydrate), APD(free acid), IG-7913, Aredia, Aminomux 【化学名称】3-Amino-1-hydroxypropylidene-1,1-diphosphonate disodium salt 【CA登记号】57248-88-1, 40391-99-9 (free acid), 109552-15-0 (pentahydrate) 【 分 子 式 】C3H9NNa2O7P2 【 分 子 量 】279.03488 |
【开发单位】Gador (Originator), Henkel (Originator), Nippon Kayaku (Not Determined), Nippon Kayaku (Marketer), Novartis (Licensee) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Bone Diseases, Treatment of, METABOLIC DRUGS, Treatment of Hypercalcemia, Treatment of Paget's Disease, Bisphosphonates, Farnesyl Pyrophosphate Synthase Inhibitors |
合成路线1
By reaction of beta-alanine (I) with the phosphorous acid and PCl3 in chlorobenzene at 100 C.
| 【1】 Krueger, F.; et al.; 1-Hydroxy-3-aminopropan-1,1-diphosphosaure und Verfahren zu deren Herstellung. DE 2130794 . |
| 【2】 Mailliet, P.; Riou, J.-F.; Laoui, A.; Mergny, J.-L.; Lavelle, F.; Petitgenet, O. (Aventis Pharma SA); Arylamine derivs. and their use as anti-telomerase agent. FR 2801588; WO 0140218 . |