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【结 构 式】 
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【药物名称】Picotamide, G-137, Plactidil 【化学名称】N,N'-Bis(3-picolyl)-4-methoxyisophthalamide 【CA登记号】32828-81-2 【 分 子 式 】C21H20N4O3 【 分 子 量 】376.41855 |
【开发单位】Samil (Originator) 【药理作用】Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Prostanoid TP (Thromboxane A2) Antagonists |
合成路线1
By condensation of 4-methoxyisophthaloyl chloride (I) with 3-picolylamine (II) by means of triethylamine in refluxing THF.
| 【1】 Selleri, R.; et al.; New 4-hydroxyisophatlic acid derivatives having anticoagulant and fibrinolytic activity. Chimie Therapeutique 1971, 6, 3, 203-207. |
| 【2】 Orzalesi, G.; Selleri, T.; Picolylamides de l'acide 4-hydroxy-isophalique, leurs dérivés méthoxylé et éthoxylé et leur procédé de fabrication. BE 0851967; FR 2100850 . |
| 【3】 Orzalesi, G.; Selleri, T. (L. Manetti & Roberts SpA); Inhibitor of blood plate aggregation. US 3973026 . |
| 【4】 Blancafort, P.; Serradell, M.N.; Castaner, J.; Hopkins, S.J.; Picotamide. Drugs Fut 1980, 5, 1, 37. |
Extended Information