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【结 构 式】 
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【药物名称】Dazodipine, Darodipine, PY-108068 【化学名称】4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 【CA登记号】72803-02-2 【 分 子 式 】C19H21N3O5 【 分 子 量 】371.39632 |
【开发单位】Novartis (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Cerebrovascular Diseases, Treatment of, Hypertension, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Calcium Channel Blockers |
合成路线1
By cyclization of ethyl acetoacetate (I), 2,1,3-benzoxadiazole-4-carboxaldehyde (II) and concentrated NH3 in refluxing ethanol.
| 【1】 Neumann, P.; CA 1105463 . |
| 【2】 Grau, M.; Castaner, J.; Serradell, M.N.; Blancafort, P.; PY-108,068. Drugs Fut 1983, 8, 2, 136. |
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