Pilsicainide hydrochloride, DU-6552, SUN-1165, Sunrythm, -Drug Synthesis Database

【结构式】

【药物名称】Pilsicainide hydrochloride, DU-6552, SUN-1165, Sunrythm

【化学名称】N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride
　　　　　　N-(2,6-Dimethylphenyl)-1-azabicyclo[3.3.0]octane-5-acetamide hydrochloride

【CA登记号】88069-49-2, 88069-67-4 (free base)

【分子式】C₁₇H₂₅ClN₂O

【分子量】308.8546

【开发单位】Daiichi Suntory Pharma (Originator), Daiichi Pharmaceutical (Licensee)

【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS, Sodium Channel Blockers

合成路线1

By condensation of 2,6-dimethylaniline (I) with 8-pyrrolizineacetlc acid (II) by means of NaH in refluxing dioxane.

【1】 Miyano, S.; Sumoto, K.; Morita, M.; Sato, F. (Suntory Ltd.); 8-(Substituted-N-phenylcarboxamidomethyl)pyrrolizidines and use thereof as antiarrhythmics. EP 0089061; JP 58159793; US 4564624 .
【2】 Thorpe, P.J.; Serradell, M.N.; Castaner, J.; SUN-1165. Drugs Fut 1985, 10, 6, 483.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17527	2,6-Xylidine; 2,6-Dimethylaniline; 2,6-Dimethylphenylamine	87-62-7	C₈H₁₁N	详情	详情
(II)	29708	2-tetrahydro-1H-pyrrolizin-7(5H)-ylacetic acid		C₉H₁₅NO₂	详情	详情

Extended Information