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【结 构 式】 
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【药物名称】LF-1695 【化学名称】1-[2-(4-Methylpiperidin-1-yl)-5-aminophenyl]-1-(4-chlorophenyl)methanone 【CA登记号】86187-86-2 【 分 子 式 】C19H21ClN2O 【 分 子 量 】328.84502 |
【开发单位】Fournier (Originator) 【药理作用】IMMUNOMODULATING AGENTS, Immunomodulators |
合成路线1
A more complete synthesis for LF-1695 has been reported: The reaction of 2-chloro-5-nitrobenzoic acid (I) with PCl5 in hot chlorobenzene gives the corresponding acyl chloride (II), which is condensed with chlorobenzene (III) by means of AlCl3, yielding 2,4'-dichloro-5-nitrobenzophenone (IV). The condensation of (IV) with 4-methylpiperidine (V) by means of K2CO3 at 150 C affords 4'-chloro-2-(4-methylpiperidin-1-yl)-5-nitrobenzophenone (VI), which is finally reduced with Fe or SnCl2 and HCl.
| 【1】 Ou, K.; Robin, J.; Bellamy, F.D.; Dodey, P.; Chazan, J.B.; Pascal, M.; Dutartre, P.; (Benzoylphenyl)piperidines: A new class of immunomodulators. J Med Chem 1991, 34, 5, 1545-52. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10188 | 2-Chloro-5-nitrobenzoic acid | 2516-96-3 | C7H4ClNO4 | 详情 | 详情 |
| (II) | 10189 | 2-Chloro-5-nitrobenzoyl chloride | 25784-91-2 | C7H3Cl2NO3 | 详情 | 详情 |
| (III) | 10190 | 1-Chlorobenzene | 108-90-7 | C6H5Cl | 详情 | 详情 |
| (IV) | 10191 | (2-Chloro-5-nitrophenyl)(4-chlorophenyl)methanone | C13H7Cl2NO3 | 详情 | 详情 | |
| (V) | 10192 | 4-Methylpiperidine; gamma-Pipecoline | 626-58-4 | C6H13N | 详情 | 详情 |
| (VI) | 10193 | (4-Chlorophenyl)[2-(4-methylpiperidino)-5-nitrophenyl]methanone | C19H19ClN2O3 | 详情 | 详情 |