• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【药物名称】Mopidralazine, MDL-899

【化学名称】N-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-(4-morpholinyl)-3-pyridazinamine
      4-[6-[(2,5-Dimethylpyrrol-1-yl)amino]-3-pyridazinyl]morpholine

【CA登记号】75841-82-6, 75841-84-8 (HCl), 77510-09-9 (sulfate)

【 分 子 式 】C14H19N5O

【 分 子 量 】273.34043

【开发单位】Lepetit (Originator)

【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Vasodilators

合成路线1

The starting compound is 3,6-dichloropyridazine (I), which is reacted with morpholine (II) in a suitable solvent to give 3-morpholino-6-chloropyridazine (III). This, upon reaction with hydrazine hydrate as solvent, gives the hydrazine derivative (IV), which by reaction with acetonylacetone (V) in acetic acid yields directly the title compound. [14C]-Labeled compound is synthesized by a microscale procedure with 45% chemical yield and 98% radiochemical purity.

1 Assandri, A.; et al.; Pharmacokinetics of a new antihypertensive pyrrolyl pyridazinamine (MDL-899) in the rat and the dog. Arzneim-Forsch Drug Res 1985, 35, 2, 508.
2 Koch, H.; Mopidralazine. Drugs Fut 1985, 10, 8, 634.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11292 3,6-Dichloropyridazine 141-30-0 C4H2Cl2N2 详情 详情
(II) 10308 2-Chloronicotinonitrile; 2-Chloro-3-cyanopyridine 6602-54-6 C6H3ClN2 详情 详情
(III) 24846 4-(6-chloro-3-pyridazinyl)morpholine C8H10ClN3O 详情 详情
(IV) 24847 4-(6-hydrazino-3-pyridazinyl)morpholine C8H13N5O 详情 详情
(V) 24848 acetonyl acetone;1,2-Diacetylethane;a,b-Diacetylethane;2,5-Diketohexane;Diacetonyl;Acetonylacetone;2,5-Dioxohexane;2,5-hexanedione 110-13-4 C6H10O2 详情 详情
Extended Information