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【结 构 式】 
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【药物名称】CI-844 【化学名称】3-Phenoxypyridine sulfate 【CA登记号】2176-45-6 (free base), 66066-82-8 (HBr salt), 66066-81-7 (HCl), 66066-84-0 (methanesulfonate) 【 分 子 式 】C11H11NO5S 【 分 子 量 】269.27802 |
【开发单位】Pfizer (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS |
合成路线1
3-Phenoxypyridine can be prepared by two different ways: 1) By reaction of 3-hydroxypyridine (I) with bromobenzene (II) by means of KOH and copper bronze at 150 C. 2) By reaction of 3-iodopyridine (III) with phenol (IV) by means of KOH and copper bronze at 150 C. The monosulfate salt is prepared by treating 3-phenoxypyridine with H2SO4.
| 【1】 Renshaw, R.R.; Conn, R.C.; Quaternary deivation of pyridyl ethers. Onium Compound. XVI. J Am Chem Soc 1937, 59, 297-301. |
| 【2】 Butler, D.E. (Pfizer Inc.); 3-Phenoxypyridine monosulfate and a method for its production. BE 0861649; DE 2755016; ES 464922; FR 2392009; GB 1559918; JP 53077068; US 4128555 . |
| 【3】 Owen, R.T.; Castaner, J.; Serradell, M.N.; CI-844. Drugs Fut 1985, 10, 4, 279. |
Extended Information