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【结 构 式】 
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【药物名称】Dopexamine, FPL-60278 【化学名称】4-[2-[[6-[(2-Phenylethyl)amino]hexyl]amino]ethyl]-1,2-benzenediol 【CA登记号】86197-47-9, 86484-52-8 (diHBr), 86484-91-5 (diHCl) 【 分 子 式 】C22H32N2O2 【 分 子 量 】356.51254 |
【开发单位】AstraZeneca (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Heart Failure Therapy, beta2-Adrenoceptor Agonists, Dopamine D1 Agonists |
合成路线1
The condensation of 6-oxo-6-[2-(3,4-dimeth oxyphenyl)ethylaminolhexanoic acid (I) with 2-phenylethylamine (II) by means of N,N'-carbonyldiimidazole in CH2Cl2 gives N-[2-(3,4-dimethoxyphenyl)ethyl]-N'-(2'-phenylethyl)hexane-1,6-diamide (III), which is reduced by means of diborane in THF yielding N-[2-(3,4 dimethoxyphenyl)ethyl-N'-(2-phenylethyl)hexane-1,6-diamine (IV). Finally, this compound is demethylated by means of refluxing 48% aqueous HBr.
| 【1】 Farmer, J.B.; Ince, F.; Brown, R.A.; Dixon, J. (Rhone-Poulenc Rorer Ltd.); Phenylethylamine derivatives and pharmaceutical use. CA 1191846; EP 0072061; US 5013760 . |
| 【2】 Prous, J.; Castaner, J.; Dopexamine. Drugs Fut 1985, 10, 8, 628. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24849 | 6-[(3,4-dimethoxyphenethyl)amino]-6-oxohexanoic acid | C16H23NO5 | 详情 | 详情 | |
| (II) | 18333 | Phenethylamine; 2-Phenyl-1-ethanamine | 64-04-0 | C8H11N | 详情 | 详情 |
| (III) | 24851 | N(1)-(3,4-dimethoxyphenethyl)-N(6)-phenethylhexanediamide | C24H32N2O4 | 详情 | 详情 | |
| (IV) | 24852 | N-(3,4-dimethoxyphenethyl)-N-[6-(phenethylamino)hexyl]amine | C24H36N2O2 | 详情 | 详情 |