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【结 构 式】 
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【药物名称】Epanolol, ICI-141292, Visacor 【化学名称】N-[2-[3-(2-Cyanophenoxy)-2-hydroxypropylamino]ethyl]-2-(4-hydroxyphenyl)acetamide 【CA登记号】86880-51-5 【 分 子 式 】C20H23N3O4 【 分 子 量 】369.42401 |
【开发单位】AstraZeneca (Originator), Taisho (Licensee) 【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, beta-Adrenoceptor Antagonists |
合成路线1
1,2-Epoxy-3-(2-cyanophenoxy)propane (I) is added to one equivalent of N-(2-aminoethyl)-4-benzyloxyphenylacetamide (II) in n-propanol and heated to reflux for 18 h, giving N-[2-(3-o-cyanophenoxy-2-hydroxypropylamino)ethyl]-4-benzyloxyphenylacetamide (III). Hydrogenolysis of the 4-benzyl moiety of (III) may be performed under mild conditions (e.g., hydrogen gas with palladium on carbon in ethanol at room temperature) to yield ICI-141292.
| 【1】 Large, M.S.; Smith, L.H.; Beta-adrenergic blocking agents. 22. 1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols. J Med Chem 1982, 25, 11, 1286. |
| 【2】 Smith, L.H. (AstraZeneca plc); Alkanolamine derivatives. BE 0872820; FR 2412521; GB 1573359 . |
| 【3】 Pento, J.T.; Day, B.W.; Epanolol. Drugs Fut 1985, 10, 5, 392. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29336 | 2-(2-oxiranyloxy)benzonitrile | C9H7NO2 | 详情 | 详情 | |
| (II) | 29337 | N-(2-aminoethyl)-2-[4-(benzyloxy)phenyl]acetamide | C17H20N2O2 | 详情 | 详情 | |
| (III) | 29338 | 1-propanol | 71-23-8 | C3H8O | 详情 | 详情 |
| (IV) | 29339 | 2-[4-(benzyloxy)phenyl]-N-(2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl)acetamide | C27H29N3O4 | 详情 | 详情 |