【结 构 式】 |
【药物名称】Dromoprednate, Ro-12-7024 【化学名称】11beta-Hydroxy-17a-(1-oxobutoxy)-D-homopregna-1,4-diene-3,20-dione 【CA登记号】66877-67-6 【 分 子 式 】C26H36O5 【 分 子 量 】428.57382 |
【开发单位】Roche (Originator) 【药理作用】Antiinflammatory Drugs, Corticosteroids |
合成路线1
The partial acylation of 11beta,17a alpha(dihydroxy-D-homopregna-1,4-diene 3,20-dione (I) with 2,2-dichloroacetyl chloride gives the corresponding compound (II), which is acylated again with butyric anhydride yielding 17a alpha-butyryloxy-11beta-dichloroacetoxy-D-homopregna-1,4-diene-3,20-dione (III). Finally, this compound is hydrolyzed partially with aqueous NH4OH and methanol.
【1】 Furst, A.; Alig, L.; Kerb, U.; Muller, M.; Wiechert, R.; Kieslich, K. (Hoffmann-La Roche, Inc.); D-Homopregnanes. US 4202841 . |
【2】 Baines, A.; Muller, M.; Domoprednate. Drugs Fut 1987, 12, 2, 118. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
17829 | 2,2-dichloroacetyl chloride; dichloroacetyl chloride | 79-36-7 | C2HCl3O | 详情 | 详情 | |
(I) | 22842 | (7R)-7-acetyl-5,7-dihydroxy-4a,6a-dimethyl-4b,5,6,6a,7,8,9,10,10a,10b,11,12-dodecahydro-2(4aH)-chrysenone | C22H30O4 | 详情 | 详情 | |
(II) | 22843 | (7R)-7-acetyl-7-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12-tetradecahydro-5-chrysenyl 2,2-dichloroacetate | C24H30Cl2O5 | 详情 | 详情 | |
(III) | 22844 | (1R)-1-acetyl-11-[(2,2-dichloroacetyl)oxy]-10a,12a-dimethyl-8-oxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydro-1-chrysenyl butyrate | C28H36Cl2O6 | 详情 | 详情 |