Batebulast hydrochloride, NCO-650, -Drug Synthesis Database

【结构式】

【药物名称】Batebulast hydrochloride, NCO-650

【化学名称】trans-4-Guanidinomethylcyclohexanecarboxylic acid 4-(1,1-dimethylethyl)phenyl ester hydrochloride

【CA登记号】83373-31-3, 81907-78-0 (free base)

【分子式】C₁₉H₃₀ClN₃O₂

【分子量】367.92285

【开发单位】Nippon Chemiphar (Originator)

【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, RESPIRATORY DRUGS, Mediator Release Inhibitors

合成路线1

By esterification of trans-4-guanidinomethylcyclohexanecarboxylic acid (I) with 4-tert-butylphenol (II) using dicyclohexylcarbodiimide as condensing agent.

参考文献中间体

【1】 Muramatsu, M.; et al.; Guanidinocyclohexanecarboxylic acid derivatives. BE 0891790; CH 652119; DE 3201817; FR 2498183; US 4465851 .
【2】 Serradell, M.N.; Castaner, J.; NCO-650. Drugs Fut 1984, 9, 8, 589.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23059	4-([[amino(imino)methyl]amino]methyl)cyclohexanecarboxylic acid		C₉H₁₇N₃O₂	详情	详情
(II)	29734	4-(tert-butyl)phenol	98-54-4	C₁₀H₁₄O	详情	详情

Extended Information