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【结 构 式】 
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【药物名称】Trientine hydrochloride, TJA-250, MK-0681, MK-681, TETA, TECZA, Syprine, Metalite, Cuprid 【化学名称】Triethylenetetramine dihydrochloride 【CA登记号】38260-01-4, 112-24-3 (free base) 【 分 子 式 】C6H20Cl2N4 【 分 子 量 】219.1591 |
【开发单位】Univar (Orphan Drug), Merck Sharp & Dohme (Originator), Univar (Not Determined), Tsumura (Licensee) 【药理作用】Antagonists to Metals, METABOLIC DRUGS, Specific Antidotes, Therapy of Disorders of Porphyrins, TREATMENT OF POISONING, DRUG ABUSE & DEPENDENCY, Wilson Disease, Agent for |
合成路线1
By condensation of ethylenediamine (I) with 1,2-dichloroethane (II).
| 【1】 Langsjoen, A.; Jones, G.D.; Zomlefer, J.; Neumann, N.M.C.; Polymerization of ethyleneimine. J Org Chem 1944, 9, 125-147. |
| 【2】 Von Hoffmann, A.W.; Zur geschichte der aethylenbasen. Ber 1890, 23, 3711-18. |
| 【3】 Walshe, J.M.; Dixon, H.B.F.; Gibbs, K.; Preparation of triethylenetetraamine dihydrochloride for the treatment of Wilson's disease. Lancet 1972, 1, 7755, 853. |
| 【4】 Castaner, J.; Serradell, M.N.; Hopkins, S.J.; Blancafort, P.; Trientine. Drugs Fut 1983, 8, 8, 697. |
Extended Information