Epalrestat, Ono-2235, Kinedak, -Drug Synthesis Database

【结构式】

【药物名称】Epalrestat, Ono-2235, Kinedak

【化学名称】(Z,E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxothiazolidine-3-acetic acid
　　　　　　(Z,E)-3-(Carboxymethyl)-5-(beta-methylcinnamylidene)rhodanine
　　　　　　(Z,E)-5-(beta-Methylcinnamylidene)-4-oxo-2-thioxothiazolidine-3-acetic acid

【CA登记号】82159-09-9

【分子式】C₁₅H₁₃NO₃S₂

【分子量】319.40376

【开发单位】Ono (Originator)

【药理作用】Antidiabetic Drugs, Diabetic Neuropathy, Agents for, ENDOCRINE DRUGS, Treatment of Diabetic Complications, Type 2 Diabetes Mellitus, Agents for, Aldose Reductase Inhibitors

合成路线1

By condensation of beta-methylcinnamylaldehyde (I) with 3-(carboxymethyl)rhodanine (II) by means of sodium acetate in refluxing acetic acid.

参考文献中间体

【1】 Hiroshi, T.; Tetsuya, M.; Takeshi, M.; Akio, A.; Masanori, K.; Fumio, H.; Tadao, T.; Masaki, H. (Ono Pharmaceutical Co., Ltd.); Rhodanine derivs., process for their preparation, . EP 0047109; US 4464382 .
【2】 Castaner, J.; Prous, J.; Epalrestat. Drugs Fut 1987, 12, 4, 336.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23083	(E)-2-methyl-3-phenyl-2-propenal	101-39-3	C₁₀H₁₀O	详情	详情
(II)	21810	2-(4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acid; 3-Carboxmethyl rhadanine; Rhodanine-N-acetic acid	5718-83-2	C₅H₅NO₃S₂	详情	详情

Extended Information