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【结 构 式】 
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【药物名称】Indometacin farnesil, Indomethacin farnesil, E-0710, Infree 【化学名称】2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 3,7,11-trimethyl-2,6,10-dodecatrienyl ester 【CA登记号】85801-02-1 【 分 子 式 】C34H40ClNO4 【 分 子 量 】562.1552 |
【开发单位】Eisai (Originator) 【药理作用】Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, Cyclooxygenase-1 Inhibitors, Cyclooxygenase-2 Inhibitors, Cyclooxygenase-3 Inhibitors, Non-Steroidal Antiinflammatory Drugs |
合成路线1
The reacion of 1-(4-chlorobenzoyl)-2-methyl-5-methoxyindolyl-3-acetic acid (I) with SOCl2 in refluxing benzene gives the corresponding acyl chloride (II), which is condensed with farnesol (III) by means of triethylamine in THF.
| 【1】 Yamatsu, I.; Abe, S.; Inai, Y.; Suzuki, T.; Kinoshita, K.; Mishima, M.; Katoh, Y.; Kobayashi, S.; Murakami, M.; Yamada, K. (Eisai Co., Ltd.); Polyprenyl esters of acemethacins and anti-inflammatory method of use thereof. DE 3226687; FR 2510107; GB 2104513; JP 8315940 . |
| 【2】 Serradell, M.N.; Castaner, J.; E-0710. Drugs Fut 1984, 9, 7, 506. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22930 | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid | C19H16ClNO4 | 详情 | 详情 | |
| (II) | 24047 | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl chloride | C19H15Cl2NO3 | 详情 | 详情 | |
| (III) | 21965 | (2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-ol | 4602-84-0 | C15H26O | 详情 | 详情 |
Extended Information