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【结 构 式】 
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【药物名称】CB-10-277(free acid), DM-COOK 【化学名称】4-(3,3-Dimethyl-1-triazenyl)benzoic acid potassium salt 【CA登记号】70055-49-1 【 分 子 式 】C9H10KN3O2 【 分 子 量 】231.30095 |
【开发单位】Institute of Cancer Research (Originator), Università degli Studi di Trieste (Originator) 【药理作用】Oncolytic Drugs |
合成路线1
1-p-(3,3-Dimethyl-1-triazeno)benzoic acid (I) Ia prepared by coupling the aryldiazonium chloride (II) with aqueous dimethylamine in an excess of sodium carbonate, and by precipitation with HCl (m.p. 170.5-1.5 C; lit. 171 C). The potassium salt is prepared by adding two equivalents of 3M KOH in MeOH to a dioxan solution of the acid. After filtration, the crude compound is dissolved in MeOH and boiled with activated charcoal; the clarified MeOH solution is diluted with ether to precipitate the purified product.
| 【1】 Kolar, G.F.; Synthesis of biologically active triazenes from isolable diazonium salts. Z Naturforsch 1972, 276, 1183-1185. |
| 【2】 Vadlamudi, S.; Loo, T.L.; Lin, Y.T.; Goldin, A.; Preparation and antitumor activity of derivatives of 1-phenyl-3,3-dimethytltriazenes. J Med Chem 1972, 15, 2, 201-203. |
| 【3】 Giraldi, T.; DM-COOK. Drugs Fut 1984, 9, 7, 503. |