Nisoldipine, Bay-k-5552, Sular, Baymycard, Syscor, -Drug Synthesis Database

【结构式】

【药物名称】Nisoldipine, Bay-k-5552, Sular, Baymycard, Syscor

【化学名称】(±)-2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl 2-methylpropyl diester

【CA登记号】63675-72-9

【分子式】C₂₀H₂₄N₂O₆

【分子量】388.42408

【开发单位】Bayer (Originator), Pharmax (Not Determined), AstraZeneca (Licensee)

【药理作用】Angina pectoris, Treatment of, CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Calcium Channel Blockers

合成路线1

By cyclization of isobutyl 2-(2-nitrobenzylidene)acetoacetate (I) and methyl 3-aminocrotonate (II) in refluxing ethanol.

参考文献中间体

【1】 Wehinger, E.; et al. (Bayer AG); 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine. US 4154839 .
【2】 McGillion, F.B.; Castaner, J.; Blancafort, P.; Serradell, M.N.; Nisoldipine. Drugs Fut 1981, 6, 6, 360.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32238	Isobutyl (Z)-2-acetyl-3-(2-nitrophenyl)-2-propenoate; Isobutyl 2-(2-nitrobenzylidene)acetoacetate		C₁₅H₁₇NO₅	详情	详情
(II)	11372	Methyl (E)-3-amino-2-butenoate; Methyl 3-aminocrotonate		C₅H₉NO₂	详情	详情

Extended Information