Ipsalazide(Rec INN; BAN), BX-650A, -Drug Synthesis Database

【结构式】

【药物名称】Ipsalazide(Rec INN; BAN), BX-650A

【化学名称】(E)-p-[(3-Carboxy-4-hydroxyphenyl)azo]hippuric acid
　　　　　　(E)-5-[[4-[(Carboxymethyl)carbamoyl]phenyl]azo]salicylic acid
　　　　　　(E)-5-[[4-[[(Carboxymethyl)amino]carbonyl]phenyl]azo]-2-hydroxybenzoic acid

【CA登记号】80573-03-1

【分子式】C₁₆H₁₃N₃O₆

【分子量】343.29851

【开发单位】Biorex Laboratories (Originator)

【药理作用】GASTROINTESTINAL DRUGS, Inflammatory Bowel Disease, Agents for

合成路线1

The diazotation of 4-aminohippuric acid (I) with NaNO2 and HCl gives the corresponding diazonium salt (II), which is then condensed with salicylic acid.

参考文献中间体

【1】 Chan, R.P.K.; 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith. DE 3128819; FR 2493312; JP 57053449; US 4412992 .
【2】 Castaner, J.; Serradell, M.N.; Balsalazide and Ipsalazide. Drugs Fut 1984, 9, 5, 313.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	34207	4-Aminohippuric acid; N-(4-aminobenzoyl)glycine; 2-[(4-aminobenzoyl)amino]acetic acid	61-78-9	C₉H₁₀N₂O₃	详情	详情
(II)	34208	4-[[(carboxymethyl)amino]carbonyl]benzenediazonium chloride		C₉H₈ClN₃O₃	详情	详情
(III)	15240	2-Hydroxybenzoic acid; Salicylic acid	69-72-7	C₇H₆O₃	详情	详情

Extended Information