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【结 构 式】 
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【药物名称】Laurocapram, N-0252, TraZone, Azone 【化学名称】1-Dodecylhexahydro-2H-azepin-2-one 【CA登记号】59277-89-3 【 分 子 式 】C18H35NO 【 分 子 量 】281.48575 |
【开发单位】UCB (Originator) 【药理作用】DRUG DELIVERY, Drug Delivery Systems |
合成路线1
By condensation of azacycloheptan-2-one (I) with 1-bromododecane (II) by means of NaH in refluxing toluene.
| 【1】 Rajadhyaksha, V.J.; Method for improved plant pest control. CA 1189338; EP 0077078; JP 58074601 . |
| 【2】 Nelson, E.L.; Method of treatment of inflammation. EP 0060970; JP 57142918; US 4310525 . |
| 【3】 Kelly, M.G.; Greenblatt, L.P.; Nelson, F.C. (American Home Products Corp.); Trisubstd. oxazole derivs. as serotonin ligands. US 6242448 . |
Extended Information