(-)-SK&F-10047, SK&F-10047, -Drug Synthesis Database

【结构式】

【药物名称】(-)-SK&F-10047, SK&F-10047

【化学名称】(-)-2'-Hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan
　　　　　　(-)-(2R,6R,11R)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol

【CA登记号】14198-28-8, 74957-58-7 (HCl), 59985-34-1 (lactate)

【分子式】C₁₇H₂₃NO

【分子量】257.37896

【开发单位】GlaxoSmithKline (Originator)

【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Opioid Analgesics, sigma Receptor Agonists

合成路线1

By condensation of 2'-hydroxy-5,9-dimethyl-6,7-benzomorphan (I) with allyl bromide (II) by means of NaHCO3 in refluxing ethanol.

参考文献中间体

【1】 Gordon, M.; Lafferty, J.J. (SmithKline Beecham Corp.); Novel N-allyl and N-propargyl benzmorphan derivs.. US 4048178 .
【2】 Serradell, M.N.; Castaner, J.; Paton, D.M.; Blancafort, P.; SKF-10,047. Drugs Fut 1983, 8, 5, 439.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36016	(1R,9R,13R)-1,13-dimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-4-ol		C₁₄H₁₉NO	详情	详情
(II)	11463	3-Bromo-1-propene; 3-Bromopropene；allyl bromide	106-95-6	C₃H₅Br	详情	详情

Extended Information