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【结 构 式】 
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【药物名称】Hexaprazol, Esaprazole hydrochloride, CO/1063, Praxol 【化学名称】N-Cyclohexyl-1-piperazineacetamide hydrochloride 【CA登记号】64204-55-3 (free base) 【 分 子 式 】C12H24ClN3O 【 分 子 量 】261.79758 |
【开发单位】Camillo Corvi (Originator) 【药理作用】Antiulcer Drugs, GASTROINTESTINAL DRUGS |
合成路线1
The reaction of cyclohexylamine (I) with chloroacetyl chloride (II) in water in the presence of sodium hydroxide gives N-cyclohexyl-2-chloro-acetamide (III), which by reaction with piperazine (IV) in water is converted to N-[(N-cyclohexylcarbamoyl)methyl]piperazine (V). This compound is then treated with one equivalent of HCl.
| 【1】 Corvi-Mora, C. (Camillo Corvi SpA); N-Cyclohexyl-piperazino acetamides and propionamides. US 4123530; US 4278796 . |
| 【2】 de Angelis, L.; Esaprazole hydrochloride. Drugs Fut 1986, 11, 4, 263. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17966 | cyclohexanamine; cyclohexyl amine; cyclohexylamine | 108-91-8 | C6H13N | 详情 | 详情 |
| (II) | 11296 | 2-Chloroacetyl chloride; Chloroacetic chloride | 79-04-9 | C2H2Cl2O | 详情 | 详情 |
| (III) | 27377 | 2-chloro-N-cyclohexylacetamide | C8H14ClNO | 详情 | 详情 | |
| (IV) | 10355 | Diethylenediamine; Piperazine | 110-85-0 | C4H10N2 | 详情 | 详情 |
| (V) | 27378 | N-cyclohexyl-2-(1-piperazinyl)acetamide | C12H23N3O | 详情 | 详情 |
Extended Information