Nonachlazine, Azaclorzine, AY-25239(hydrochloride), -Drug Synthesis Database

【结构式】

【药物名称】Nonachlazine, Azaclorzine, AY-25239(hydrochloride)

【化学名称】2-Chloro-10-[3-(hexahydropyrrolo[1,2-a]pyrazin-2[1H]-yl)propionyl]-phenothiazine
　　　　　　2'-Chloro-10'-[beta-N-(1,4-diazabicyclo-[4,3-0]-propionyl]phenothiazine

【CA登记号】49864-70-2, 49780-10-1 (HCl)

【分子式】C₂₂H₂₄ClN₃OS

【分子量】413.97308

【开发单位】Russian Academy of Medical Sciences (Originator)

【药理作用】Angina pectoris, Treatment of, CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Vasodilators

合成路线1

By condensation of 2-chloro-10-(beta-chloropropionyl)phenothiazine (I) with 1,4-diazabicylo[4.3.0]nonane (II) in refluxing toluene.

参考文献中间体

【1】 Markova, G.A.; Kaverina, N.V.; pharmacology of the new anti-anginal frug nonachlazine. Farmakol Toksikol 1975, 38, 2, 173.
【2】 Likhosherstov, A.M.; et al.; 10'-(Omega-N-1,4-Diazabyzyklo-4,m,O-alkanylacyl)phenothiazine, ihre Saureadditionssalze und ihre quaternaren Salze, Verfahren zu ihrer Herstellung und ihre Andwendung. DE 2210382 .
【3】 Blancafort, P.; Castaner, J.; Azaclorzine. Drugs Fut 1976, 1, 4, 157.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	40335	3-chloro-1-(2-chloro-10H-phenothiazin-10-yl)-1-propanone		C₁₅H₁₁Cl₂NOS	详情	详情
(II)	40336	octahydropyrrolo[1,2-a]pyrazine		C₇H₁₄N₂	详情	详情

Extended Information