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【结 构 式】 
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【药物名称】Diclondazolic acid, Lonidamine, KN-228, AF-1890, Doridamina 【化学名称】1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid 【CA登记号】50264-69-2 【 分 子 式 】C15H10Cl2N2O2 【 分 子 量 】321.16515 |
【开发单位】Angelini (Originator), Kanebo (Licensee), Nippon Shinyaku (Licensee) 【药理作用】Oncolytic Drugs |
合成路线1
By condensation of 1H-indazole-3-carboxylic acid (I) with 2,4-dichlorobenzyl chloride (II) by means of NaOH in water heated over a steam bath.
| 【1】 Corsi, G.; Palazzo, G.; 1-Halobenzyl-1H-3-carboxylic acids. A new class of antispermatogenic agents. J Med Chem 1976, 19, 6, 778-783. |
| 【2】 Palazzo, G.; Silvestrini, B. (ACRAF SpA); Substituted 1-benzyl-1H-indazole-3-carboxylic acids and derivatives thereof. DE 2310031; FR 2181773; GB 1381422; US 3895026 . |
| 【3】 Hillier, K.; Lonidamine. Drugs Fut 1979, 4, 4, 265. |
Extended Information