【结 构 式】 |
【药物名称】Mefenidil, McN-2378-46(fumarate), McN-2378 【化学名称】5-Methyl-2-phenyl-1H-imidazole-4-acetonitrile 【CA登记号】58261-91-9, 83153-38-2 (fumarate) 【 分 子 式 】C12H11N3 【 分 子 量 】197.24157 |
【开发单位】Ortho-McNeil (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Vasodilators |
合成路线1
The cyclization of benzamidine (I) with biacetyl (II) in water - isopropanol gives 4,5-dimethyl-2-phenylimidazoline-4,5-diol (III), which by treatment with refluxing aqueous 10% HCl is converted into 4-hydroxymethyl-2-phenyl-5-methylimidazole (IV). The reaction of (IV) with SOCl2 in refluxing benzene yields 4-chloromethyl-2-phenyl-5-methylimidazole (V), which is finally treated with NaCN in DMSO - water.
【1】 Rasmussen, C.R.; 2-Aryl-4-cyanomethyl-5-methylimidazoles. DE 2528640; FR 2296627; FR 2309540; FR 2309541; GB 1502142; JP 51034159; US 4093811 . |
【2】 Blancafort, P.; Hillier, K.; Serradell, M.N.; Castaner, J.; McN-2378. Drugs Fut 1982, 7, 4, 262. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 37052 | Benzamidine; benzenecarboximidamide | C7H8N2 | 详情 | 详情 | |
(II) | 37053 | biacetyl | 431-03-8 | C4H6O2 | 详情 | 详情 |
(III) | 37054 | 4,5-dimethyl-2-phenyl-4,5-dihydro-1H-imidazole-4,5-diol | C11H14N2O2 | 详情 | 详情 | |
(IV) | 37055 | (5-methyl-2-phenyl-1H-imidazol-4-yl)methanol | C11H12N2O | 详情 | 详情 | |
(V) | 37056 | 4-(chloromethyl)-5-methyl-2-phenyl-1H-imidazole | C11H11ClN2 | 详情 | 详情 |
Extended Information