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【结 构 式】

【药物名称】Mefenidil, McN-2378-46(fumarate), McN-2378

【化学名称】5-Methyl-2-phenyl-1H-imidazole-4-acetonitrile
      4-Cyanomethyl-2-phenyl-5-methylimidazole

【CA登记号】58261-91-9, 83153-38-2 (fumarate)

【 分 子 式 】C12H11N3

【 分 子 量 】197.24157

【开发单位】Ortho-McNeil (Originator)

【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Vasodilators

合成路线1

The cyclization of benzamidine (I) with biacetyl (II) in water - isopropanol gives 4,5-dimethyl-2-phenylimidazoline-4,5-diol (III), which by treatment with refluxing aqueous 10% HCl is converted into 4-hydroxymethyl-2-phenyl-5-methylimidazole (IV). The reaction of (IV) with SOCl2 in refluxing benzene yields 4-chloromethyl-2-phenyl-5-methylimidazole (V), which is finally treated with NaCN in DMSO - water.

1 Rasmussen, C.R.; 2-Aryl-4-cyanomethyl-5-methylimidazoles. DE 2528640; FR 2296627; FR 2309540; FR 2309541; GB 1502142; JP 51034159; US 4093811 .
2 Blancafort, P.; Hillier, K.; Serradell, M.N.; Castaner, J.; McN-2378. Drugs Fut 1982, 7, 4, 262.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 37052 Benzamidine; benzenecarboximidamide C7H8N2 详情 详情
(II) 37053 biacetyl 431-03-8 C4H6O2 详情 详情
(III) 37054 4,5-dimethyl-2-phenyl-4,5-dihydro-1H-imidazole-4,5-diol C11H14N2O2 详情 详情
(IV) 37055 (5-methyl-2-phenyl-1H-imidazol-4-yl)methanol C11H12N2O 详情 详情
(V) 37056 4-(chloromethyl)-5-methyl-2-phenyl-1H-imidazole C11H11ClN2 详情 详情
Extended Information