FKK, LS-128974, -Drug Synthesis Database

【结构式】

【药物名称】FKK, LS-128974

【化学名称】2,3-Dihydro-7-methyl-9-phenyl-1H-pyrazolo[1,2-a]indazolium bromide monohydrate

【CA登记号】78299-79-3

【分子式】C₁₇H₁₉BrN₂O

【分子量】347.25778

【开发单位】Chugai (Originator)

【药理作用】Asthma Therapy, Bronchodilators, RESPIRATORY DRUGS

合成路线1

By cyclization of 5-methyl-3-phenylindazole (I) with 1,3-dibromopropane (II) by means of NaH in DMF or triethylbenzylammonium chloride NaOH in toluene - water.

参考文献中间体

【1】 Fujimura, Y.; et al.; Pyrazoloindazole derivatives and bronchodilating composition. EP 0023633; JP 56015287; US 4409234 .
【2】 Sakai, K.; Shiraki, Y.; Pharmacologic potency and selectivity of a new bronchodilator agent, 2,3-dihydro-7-methyl-9-phenyl-1H-pyrazolo[1,2-a]indazolium bromide (FKK) on canine tracheal preparations 'in vivo' and 'in vitro'. Arch Intl Pharmacodyn Ther 1983, 262, 1, 150-163.
【3】 Serradell, M.N.; Castaner, J.; Chu, S.S.; FKK. Drugs Fut 1984, 9, 4, 264.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	31937	Triethylbenzylammonium chloride; N-benzyl-N,N-diethyl-1-ethanaminium chloride; Benzyltriethylammonium chloride	56-37-1	C₁₃H₂₂ClN	详情	详情
(I)	34172	5-methyl-3-phenyl-1H-indazole		C₁₄H₁₂N₂	详情	详情
(II)	12581	1,3-Dibromopropane	109-64-8	C₃H₆Br₂	详情	详情

Extended Information