Fenoximone, Enoximone, MDL-17043, RMI-17043, Perfan, Perfane, -Drug Synthesis Database

【结构式】

【药物名称】Fenoximone, Enoximone, MDL-17043, RMI-17043, Perfan, Perfane

【化学名称】4-Methyl-5-[p-(methylthio)benzoyl]-4-imidazolin-2-one
　　　　　　1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one

【CA登记号】77671-31-9

【分子式】C₁₂H₁₂N₂O₂S

【分子量】248.30564

【开发单位】Aventis Pharma (Originator), Lepetit (Originator), Myogen (Licensee)

【药理作用】CARDIOVASCULAR DRUGS, Heart Failure Therapy, cAMP Phosphodiesterase Inhibitors, Phosphodiesterase III Inhibitors

合成路线1

The reaction of 4-(methylthio)benzoic acid (I) with SOCl2 in refluxing benzene gives 4-(methylthio)benzoyl chloride (II), which is then condensed with 1,3-dihydro-4-methyl-2H-imidazol-2-one (III) by means of AlCl3 in hot nitrobenzene.

参考文献中间体

【1】 Dage, R.C.; Schnettler, R.A.; Grisar, J.M. (Aventis Pharmaceuticals, Inc.); 4-Aroylimidazol-2-ones. BE 0883856; DE 3021792; FR 2459233; GB 2055364; JP 56005463 .
【2】 Pento, J.T.; Serradell, M.N.; Castaner, J.; Blancafort, P.; RMI-17,043. Drugs Fut 1983, 8, 4, 343.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30683	4-(methylsulfanyl)benzoic acid	13205-48-6	C₈H₈O₂S	详情	详情
(II)	21238	4-(methylsulfanyl)benzoyl chloride		C₈H₇ClOS	详情	详情
(III)	30684	4-methyl-1,3-dihydro-2H-imidazol-2-one		C₄H₆N₂O	详情	详情

Extended Information