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【结 构 式】 
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【药物名称】Ru-24969 【化学名称】5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole succinate 【CA登记号】66611-27-6 ((2:1) salt), 66611-26-5 (free base) 【 分 子 式 】C18H22N2O5 【 分 子 量 】346.38644 |
【开发单位】Aventis Pharma (Originator) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, 5-HT1A Receptor Agonists, 5-HT1B Agonists |
合成路线1
By condensation of 5-methoxyindole (I) with 4-piperidone (II) in acetic acid at 100 C, followed by neutralization with succinic acid (A).
| 【1】 Dumont, C.; et al. (Aventis Pharma SA); Treating psychic disorders with piperidylindoles. ES 461875; FR 2362628; GB 1556919; JP 53028178; US 4196209 . |
| 【2】 Serradell, M.N.; Castaner, J.; Blancafort, P.; Paton, D.M.; RU-24,969. Drugs Fut 1981, 6, 3, 157. |
Extended Information