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【结 构 式】

【药物名称】Pinacidil, S-1230, P-1134, Pindac

【化学名称】(±)-N'-Cyano-N-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine monohydrate

【CA登记号】85371-64-8, 60560-33-0 (anhydrous)

【 分 子 式 】C13H21N5O

【 分 子 量 】263.34522

【开发单位】Leo (Originator)

【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, K(ATP) Channel Activators

合成路线1

This compound can be obtained in two related ways: 1) By reaction of N-(4-pyridyl)-N'-(1,2,2-trimethylpropyl)thiourea (I) with cyanamide (II) by means of dicyclohexylcarbodiimide (DCC) and ethyldiisopropylamine in ether. 2) The reaction of (I) with phosgene in toluene - THF by means of ethyldiisopropylamine in THF gives N-(4-pyridyl)-N'-(1,2,2-trimethylpropyl)carbodiimide (III), which is condensed with (II) by means of ethyldiisopropylamine.

1 Petersen, H.J. (Leo Pharmaceutical Products Ltd. A/S); Antihypertensive pyridylguanidine compounds. DE 2557438; FR 2294703; GB 1489879; JP 51086474; US 4057636 .
2 Blancafort, P.; Castaner, J.; Serradell, M.N.; Hopkins, S.J.; P-1134. Drugs Fut 1981, 6, 3, 149.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 32176 N-(4-pyridyl)-N'-(1,2,2-trimethylpropyl)thiourea; N-(4-pyridinyl)-N'-(1,2,2-trimethylpropyl)thiourea C12H19N3S 详情 详情
(II) 19648 Cyanamide 420-04-2 CH2N2 详情 详情
(III) 32177 N-(4-pyridinyl)-N'-(1,2,2-trimethylpropyl)carbodiimide; N-(4-pyridyl)-N'-(1,2,2-trimethylpropyl)carbodiimide C12H17N3 详情 详情
Extended Information