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【结 构 式】 
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【药物名称】Sofalcone 【化学名称】2-[5-(3-Methyl-2-butenyloxy)-2-[3-[4-(3-methyl-2-butenyloxy)phenyl]-2(E)-propenoyl]phenoxy]acetic acid 【CA登记号】64506-49-6 【 分 子 式 】C27H30O6 【 分 子 量 】450.53655 |
【开发单位】Taisho (Originator) 【药理作用】Antiulcer Drugs, GASTROINTESTINAL DRUGS |
合成路线1
The reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (I) with ethyl bromoacetate (II) by means of KOH in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (III), which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (IV) by means of KOH in ethanol.
| 【1】 Grau, M.; Castaner, J.; Blancafort, P.; Serradell, M.N.; SU-88. Drugs Fut 1983, 8, 6, 513. |
| 【2】 Kyogoku, K.; Hatayama, K.; Yokomori, S.; Sawada, J.; Tanaka, I. (Taisho Pharmaceutical Co., Ltd.); 2-(Carboxymethoxy)chalcones. DE 2705603; ES 455620; FR 2340924; GB 1523241; JP 52097950; US 4085135 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16637 | 1-[2-hydroxy-4-[(3-methyl-2-butenyl)oxy]phenyl]-1-ethanone | C13H16O3 | 详情 | 详情 | |
| (II) | 16640 | Ethyl 2-bromoacetate; Ethyl bromoacetate | 105-36-2 | C4H7BrO2 | 详情 | 详情 |
| (III) | 36017 | ethyl 2-[2-acetyl-5-[(3-methyl-2-butenyl)oxy]phenoxy]acetate | C17H22O5 | 详情 | 详情 | |
| (IV) | 19019 | 4-[(3-methyl-2-butenyl)oxy]benzaldehyde | C12H14O2 | 详情 | 详情 |
Extended Information