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【结 构 式】 
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【药物名称】Imagent 【化学名称】tetradecafluoro-hexane;Perfluorohexane;Tetradecafluorohexane 【CA登记号】355-42-0 【 分 子 式 】C6F14 【 分 子 量 】338.04 |
【开发单位】Alliance Pharm 【药理作用】用于超声波心脏扫描记录的辅助药物 |
合成路线1
| 【1】 Abe T. Pandey SK, Baba H. 2000. Electrochemical fluorination of hexahydroazepine, methylpiperidines and methyl l-hexahydroazepine-acetate: the preparation of F-(l-hexahydroazepine-acetyl fluoride) and its derivatives. J Fluor Chem, 105(1):149--157 |
合成路线2
| 【1】 Zhao CX, Chen GF, Jiang, XK, et al. 1987. The chemistry of diacyl peroxides. VIII. The reactions between polyfluorodiacyl peroxides and 2-nitro-2-nitrosopropane-generation of bis(polyfluoroalkyl) nitroxides. J Fluor Chem, 35: 597～606 |
| 【2】 Zhao CX, Qu YL, Jiang XK, et al. 1985. Chemistry of diacyl peroxides. IV. Single electron transfer reaction between perfluorodiacyl peroxides and carbanions derived from nitroalkanes-a new method for synthesis of aldehydes or ketones. 化学学报，43: 1184～1199 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
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合成路线3
合成路线4
| 【1】 Henne AL, Fox CJ. 1953. Ionization constant of fluorinated acids. TI. J Am Chem Soc, 75: 5750一5751 |
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