| Targets |
Details 1. Glycylpeptide N-tetradecanoyltransferase- Kind
- Protein
- Organism
- Yeast
- Pharmacological action
- unknown
- General Function:
- Glycylpeptide n-tetradecanoyltransferase activity
- Specific Function:
- Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6. Basic residues are preferred at positions 7 and 8.
- Gene Name:
- NMT1
- Uniprot ID:
- P30418
- Molecular Weight:
- 51876.7 Da
References- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Details 2. Glycylpeptide N-tetradecanoyltransferase 1- Kind
- Protein
- Organism
- Human
- Pharmacological action
- unknown
- General Function:
- Glycylpeptide n-tetradecanoyltransferase activity
- Specific Function:
- Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
- Gene Name:
- NMT1
- Uniprot ID:
- P30419
- Molecular Weight:
- 56805.865 Da
References- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
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