avalglucosidase alfa - Drug Dictionary

Drug Name	avalglucosidase alfa
Chemical Name	mutated human acid α-glucosidase produced in Chinese hamster ovary (CHO) cells, glycoform alfa, conjugated to a synthetic branched hexasaccharide containing two terminal mannose-6-phosphate (M6P), via aminooxy linkers;[His143>Arg,Arg167>His,Val724>Ile]prepro-lysosomal α-glucosidase (EC=3.2.1.20) (human) (57-2)-peptide,expressed in CHO cells, glycoform alfa, with 5~9 sialyl end groups of glycan residues being oxidized and chemically modified to 5-acetamido-3,5,7-ideoxy-7-[(E)-(2-oxo-2-{2-[4-({O-(6-O-phosphono-α-D-mannopyranosyl)-(1→2)-O-α-D-mannopyranosyl-(1→6)-O-α-D-mannopyranosyl-(1→6)-O-[O-(6-O-phosphono-α-D-mannopyranosyl)-(1→2)-O-α-Dmannopyranosyl-(1→3)]-β-Dmannopyranosyl}oxy)butanoyl]hydrazinyl}ethoxy)imino]-β-L-arabino-2-heptulo-2,6-pyranosylonic acid roups
CAS No.	1802558-87-7
Structure

Extended Information

EMA Approvals(1) CDE Approvals(5) CFDA Approvals(Import))(1)